preparation, characterization and in vitro studies of chitosan nanoparticles containing androctonus crassicauda scorpion venom

Preparation, Characterization and in vitro Studies of Chitosan Nanoparticles Containing Androctonus Crassicauda scorpion venom

Many strategies have been developed to improve vaccine delivery in the past decade. The aim of the current study was to develop a nanoparticulate system based on ionic gelation between chitosan and tripolyphosphate in order to load Androctonus Crassicauda scorpion venom. The best formulation was selected according to the highest association efficiency, loading capacity, optimum particle size an...

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Molecular Characterization of a Three-disulfide Bridges Beta-like Neurotoxin from Androctonus crassicauda Scorpion Venom

Scorpion venom is the richest source of peptide toxins with high levels of specific interactions with different ion-channel membrane proteins. The present study involved the amplification and sequencing of a 310-bp cDNA fragment encoding a beta-like neurotoxin active on sodium ion-channel from the venom glands of scorpion Androctonus crassicauda belonging to the Buthidae family using r...

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Effects of Black Scorpion Androctonus crasicuda Venom on Striated Muscle Preparation in vitro.

Effects of venom from black scorpion Androctonus crasicuda (AC) were determined on isolated chick biventer cervices nerve-muscle and mouse hemidiaphragm preparations using twitch tension method. The isolated nerves were stimulated by electrical stimulator and response to each stimulus was recorded. The venom mainly acted prejunctionally to facilitate neuromuscular activity due to an increase in...

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Effects of Black Scorpion Androctonus crasicuda Venom on Striated Muscle Preparation in vitro.

Effects of venom from black scorpion Androctonus crasicuda (AC) were determined on isolated chick biventer cervices nerve-muscle and mouse hemidiaphragm preparations using twitch tension method. The isolated nerves were stimulated by electrical stimulator and response to each stimulus was recorded. The venom mainly acted prejunctionally to facilitate neuromuscular activity due to an increase in...

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Antigenic Cross-Reactivity Anti-Birtoxin Antibody against Androctonus crassicauda Venom

BACKGROUND Antivenom is still widely used in the treatment of envenomation as there are no vaccines or other effective agents available against animal venoms. Recently, neurotoxins named birtoxin family have been described from Parabuthus transvaalicus and Androctonus crassicauda. The aim of the present study was to test the anti-birtoxin antibodies for their ability to neutralize the lethal ef...

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Preparing and Characterizing Chitosan Nanoparticles Containing Hemiscorpius lepturus Scorpion Venom as an Antigen Delivery System

In recent years, chitosan nanoparticles have been studied widely for protein delivery. In this study, Hemiscorpius lepturus (HL) venom was encapsulated in chitosan nanoparticles. The aim of the present work was to carry out a systematic study for preparing biocompatible and biodegradable nanoparticles for loading HL scorpion venom and to evaluate their potential as an antigen delivery system. I...

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preparation, characterization and in vitro studies of chitosan nanoparticles containing androctonus crassicauda scorpion venom

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